In the context of the Master of the house rising up and shutting the door (to heaven) in the Day of Judgment, the Lord Jesus commands those knocking on the door to depart from Him:
Luke 13:27 But he shall say, I tell you, I know you not whence ye are; depart from me, all ye workers of iniquity.
The Greek word translated as "depart" is also found in the parable of the sower where its translated as "fall away":
Luke 8:13 They on the rock are they, which, when they hear, receive the word with joy; and these have no root, which for a while believe, and in time of temptation fall away.
In this time of severe testing and of the world's final judgment we see that some people who once seemingly had understanding of faithful Bible doctrines (such as the Sunday Sabbath, the faith of Christ, the end of the Church Age, the Biblical calendar of history, etc, etc) are falling away from those same doctrines they once professed to believe and understand. However, as the Scriptures above show, when those people have no root (Christ) in themselves and fall away in times of temptation, this is simply the outworking of the Lord Jesus' command to those rebels who insist upon God that the door must be open prompting Christ to make His declaration: "depart from Me, all ye workers of iniquity". Their departure (falling away) from the faith is a result of Jesus commanding it to be so.
The same word "depart" is used in this verse also:
1 Timothy 4:1 Now the Spirit speaketh expressly, that in the latter times some shall depart from the faith, giving heed to seducing spirits, and doctrines of devils;